Hypothiocyanous acid oxidation of tubulin cysteines inhibits microtubule polymerization
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چکیده
منابع مشابه
Hypothiocyanous acid oxidation of tubulin cysteines inhibits microtubule polymerization.
Thiol oxidation is a probable outcome of cellular oxidative stress and is linked to degenerative disease progression. In addition, protein thiol redox reactions are increasingly identified as a mechanism to regulate protein structure and function. We assessed the effect of hypothiocyanous acid on the cytoskeletal protein tubulin. Total cysteine oxidation by hypothiocyanous and hypochlorous acid...
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2-[(1-methylpropyl)dithio]-1H-imidazole (IV-2) is a known inhibitor of the thioredoxin system. It causes the oxidation of cysteine residues from both thioredoxin reductase and thioredoxin, with only the latter leading to irreversible inhibition of protein function. Although IV-2 is considered to be the first specific inhibitor of thioredoxin to undergo evaluation in cancer patients (under the n...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2014
ISSN: 0003-9861
DOI: 10.1016/j.abb.2013.10.026